A new weight-loss trend involving microdosing the diabetes medication Ozempic has sparked interest among individuals seeking to shed pounds. Ozempic, along with Wegovy, is manufactured by Novo Nordisk, with Ozempic approved for managing type 2 diabetes and Wegovy designed for obesity treatment. While weight-loss drugs are gaining popularity in the U.S., where roughly 70% of adults are considered overweight or obese, experts caution that microdosing Ozempic carries risks.
What Is Microdosing Ozempic?
Microdosing refers to using smaller-than-prescribed doses of Ozempic, which is typically administered in weekly injections. Some people have begun experimenting with daily, reduced doses in the hope of achieving weight loss benefits while minimizing side effects. Dr. Alexandra Sowa, an obesity medicine specialist and founder of SoWell in New York, explains that Ozempic is the only injectable medication in this class that can be “hacked” for smaller doses, making it more accessible for some users.
The Appeal of Microdosing
Microdosing Ozempic has become appealing for several reasons, with many hoping to save on the medication’s high costs. A typical monthly supply of Ozempic can exceed $1,000, a burden for many without insurance. Microdosing might seem like a way to stretch the medication further, with individuals using as little as 10% of the prescribed dose. This practice is often driven by a desire to manage finances rather than evidence-based recommendations.
The Risks and Lack of Approval
Experts warn that microdosing Ozempic is not approved by the U.S. Food and Drug Administration (FDA), and there are no clinical studies supporting the practice. Dr. Fatima Cody Stanford, an obesity medicine physician at Massachusetts General Hospital, notes that standard dosing regimens are based on rigorous clinical trials designed to ensure safety and effectiveness. Lower doses might not provide the same therapeutic benefits, leading to suboptimal weight loss or ineffective blood sugar management.
Some individuals also pursue microdosing to mitigate common side effects such as nausea or stomach discomfort. Dr. Christopher McGowan, an obesity specialist in North Carolina, explains that patients may start with microdoses to acclimate their bodies to the medication before moving to the full dose. However, this could ultimately reduce the drug’s efficacy.
The Dangers of Compounded Versions
Another concern is the use of compounded versions of Ozempic, which are not regulated by the FDA. These products are often purchased outside of traditional pharmacy channels and can carry risks such as contamination or inconsistent dosages. Dr. McGowan warns that microdosing with compounded Ozempic could lead to “macrodosing” by mistake, resulting in dangerous doses of the drug.
The Placebo Effect and Supply Challenges
Dr. Amy Rothberg, a professor at the University of Michigan, notes that some users might experience a placebo effect when microdosing, believing they are benefiting from the smaller doses despite a lack of proven clinical support. Additionally, microdosing may be seen as a way to extend limited supplies of the medication, but this does not guarantee weight loss or improved health outcomes.
Expert Opinions on Microdosing
While some healthcare professionals, like Dr. Suzanne A. Trott, a Beverly Hills-based plastic and general surgeon, believe microdosing can be safe if monitored by a physician, experts generally agree that it is an off-label and unproven practice. Dr. Trott, who operates a microdosing clinic, suggests that microdosing Ozempic is similar to other off-label uses of medication, such as the use of Botox or fillers.
However, most experts stress that weight loss is most successful when combined with lifestyle changes, including a balanced diet and regular exercise. Dr. Rothberg points out that without these behavioral modifications, the long-term benefits of Ozempic will likely fade once the drug is discontinued.
Conclusion: Proceed with Caution
While microdosing Ozempic is a trend growing in popularity, it remains an unapproved and untested practice. Those considering it should consult a healthcare professional to weigh the potential risks and benefits. As always, experts emphasize that sustainable weight loss requires more than just medication—it requires lasting changes to diet and physical activity.
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