Diet pills are a favorite of many obese people. However, obese people often have many misunderstandings in the application, and it is helpful to remember the following points for your weight loss.
First, weight loss is ultimately about reducing body fat mass and increasing muscle mass as much as possible. Therefore, controlling excessive energy intake and increasing physical energy consumption through exercise will cause negative energy balance in a period of time, so as to achieve the purpose of using body fat. This is the foundation and basic treatment. Any weight loss pill must be based on this in order to be effective.
Second, diet pills have not made great progress at present. Pharmacologically, diet drugs can be divided into two categories: they act through several phenolamine pathways in the brain. The representative drug in this category is amphetamine, because it has a strong stimulating effect and can lead to addiction. application. The other type works through the brain serotonin pathway. The representative drug is fenfluramine, which is still playing a leading role in weight loss drugs. The main reason is that at the usual dose, the patient can take it for a long time, and it can be well tolerated without obvious side effects, which is exactly what the patient needs. In addition, one of the most striking reasons for fenfluramine is that it has a certain lowering of blood insulin concentration. Hyperinsulinemia is related to a variety of important diseases, such as hypertension, coronary heart disease, and obesity, which opens up a large space for its application. It is very interesting that some human diseases often have the phenomenon of “accompanying”, and the reason is hyperinsulinemia. Therefore, reducing the increased insulin in the blood has become the key to “comprehensive management”. It is conceivable that fenfluramine is one of them. Can play an active role.
Third, some studies have pointed out that fenfluramine has a certain hypoglycemic effect on obese diabetes, and some people began to suspect that this effect is achieved through weight loss, but studies have shown that the hypoglycemic effect of the drug may be another way, namely Improves and enhances tissue sensitivity to insulin. The initial dose of fenfluramine is 10-20 mg per day, and it can be gradually increased to 20-60 mg per day (3 times, before meals) to reduce side effects. At present, dexfenfluramine, which is stronger than this drug and has fewer side effects, is under development and has wider application value.
