As early as 2001, the medical community put forward the concept of obesity as a disease, and believed that obesity should be supplemented with drug treatment and should be carried out under the guidance of doctors. So, how many drugs can treat obesity? The following is a brief description for patients’ reference.
Appetite-suppressing drugs mainly suppress appetite by regulating food intake and satiety centers, so as to achieve the purpose of weight loss. Such drugs mainly include amphetamine and its derivatives, indole and its derivatives, and pseudo-serotonin neurotransmitter drugs.
Specific drugs such as fenfluramine (also known as fenfluramine), bupropion (also known as diethyl benzophenone), fenfluramine (also known as moindole), dexfenfluramine (redox) ), o-Chlorphentermine, Amirez, etc. Such drugs have central effects, among which amphetamines are psychotropic drugs, such as bupropion, which belongs to a class of psychotropic drugs under special management. The drugs that affect digestion and absorption mainly include edible fiber (containing polysaccharide, lignin, hemicellulose, resin, alginate, etc.), which can promote gastric emptying, inhibit the decomposition of food in the gastrointestinal tract, reduce energy and nutrient absorption, increase Satiety and reduce food intake to achieve the purpose of weight loss. The sucrose polyester used in the fake diet therapy for weight loss is a dietary fat substitute, which is not digested and absorbed after eating and is excreted with the feces, thereby reducing the source of calories.
In addition, the use of some drugs can prevent the side effects of digestion and absorption, reduce the body’s absorption and utilization of energy, so as to achieve weight loss effects, such as the use of erythromycin (macrolide drugs) and the gastrointestinal reactions of similar drugs to interfere with appetite ;Using cholestyramine to combine with intestinal bile acid to make fat emulsification difficult to cause steatorrhea, resulting in a weight loss effect; large doses of biguanide oral hypoglycemic drugs such as phenformin (Jiantangling), metformin (Jiangtang tablets, metformin) Etc., can cause indigestion, affect appetite, thereby reducing or delaying the absorption of sugar in the gastrointestinal tract, and can increase the excretion of lipids, receive weight loss effect. However, these are the use of side effects of drugs after all, and they should be used with caution. Drugs that have been used in the treatment of obesity in recent years and are being studied
- Sibutramine (also known as Qumei, Aoquqing, Kexiu, Tingli, Nuomeiting, etc., of which Nuomeiting is a German product) is the first weight loss prescription drug approved by the State Food and Drug Administration in 2000. The medicine enhances the sense of satiety by inhibiting the reuptake of norepinephrine and serotonin, which can reduce the hunger of the human body without affecting the body’s absorption of normal essential nutrients, and make the body fat naturally consume to achieve the purpose of weight loss, However, the drug still has a central effect and is dose-dependent.
- Orlistat (also known as orlistat, trade name Senecol) is a new type of non-central nervous weight loss drug that was launched in China in 2001. It can selectively act on gastrointestinal lipase, making it inactive and unable to Fats (mainly triglycerides) in food are hydrolyzed into absorbable free fatty acids and monoacylglycerols, and undigested triglycerides cannot be absorbed by the body, thereby reducing caloric intake and controlling body weight.
- L-carnitine (also known as carnitine) is an amino acid widely present in the human body, which can transport long-chain fat into mitochondria for oxidative decomposition. If the body lacks L-carnitine, it can affect fat metabolism and cause obesity. Therefore, by supplementing L-carnitine to develop and utilize fat, it can be converted into energy and consumed to achieve the purpose of weight loss.
- Leptin is a polypeptide hormone expressed by obesity genes. It suppresses appetite by acting on the appetite center and improves the energy metabolism rate in the body to achieve the purpose of weight loss. The hot spot in the field of diabetes research is currently in the research stage.
