Recent research indicates that the weight loss effects of semaglutide medications, such as Ozempic and Wegovy, may differ significantly between men and women. The study, published in JAMA Network Open on September 13, provides new insights into how these weight loss drugs impact individuals differently than previous trials suggested.
Findings from the New Study
The study analyzed medical records from nearly 3,500 patients prescribed semaglutide or liraglutide, the latter being a medication used for type 2 diabetes that also contributes to weight loss. The results revealed an average weight loss of approximately 3.7 percent over one year. Specifically, patients using semaglutide lost about 5.1 percent of their body weight, while those taking liraglutide experienced a 2.2 percent reduction.
In contrast to earlier research showing up to 20 percent weight loss with these medications, this study found a more modest impact. Notably, the weight loss was more significant in patients using semaglutide for obesity, who lost 12.9 percent of their body weight after a year, compared to 5.9 percent for those using it for diabetes.
Gender Differences in Weight Loss
The study also highlighted that women were more likely to experience substantial weight loss with semaglutides compared to men. Women in the study were found to be 57 percent more likely to lose at least 10 percent of their body weight over the year.
Factors Influencing Weight Loss
According to Mir Ali, MD, a bariatric surgeon and medical director at MemorialCare Surgical Weight Loss Center, individual results can vary widely. While the study indicates women may generally lose more weight with semaglutide, results can differ based on various factors including patient-specific variables and the presence of underlying health conditions.
Dr. Kunal Shah, an endocrinologist at Rutgers Robert Wood Johnson Medical Center, suggests that hormonal differences might contribute to these findings. “Hormones are a significant factor in weight management. Since these medications are hormone analogues, they may have a more pronounced effect in women,” he explained.
Additionally, Shah notes that women often have lower body mass than men, which could make the medications more effective for them.
Considerations Before Starting Semaglutide
Before starting semaglutide or similar medications, there are several important factors to consider:
Insurance Coverage: Long-term use of these medications can be costly, and insurance coverage varies. Patients should ensure they have adequate insurance to avoid unexpected expenses.
Gastrointestinal Issues: Semaglutide can exacerbate gastrointestinal conditions like irritable bowel syndrome (IBS), so individuals with such conditions should consult their healthcare provider.
Obesity Classification: These medications are typically prescribed for individuals classified as having obesity. A healthcare provider can determine eligibility based on medical criteria.
Dr. Ali emphasizes the importance of combining medication with lifestyle changes. “Successful patients use these medications as part of a broader strategy that includes dietary and lifestyle adjustments,” he said. “These tools are most effective when they support long-term health habits.”
Conclusion
This latest research underscores the nuanced effects of semaglutide medications on weight loss, particularly highlighting gender differences. While the medications can aid in weight reduction, individual results vary, and a comprehensive approach involving lifestyle changes remains crucial for sustained success.
Related Topic:
Can You Lose Weight Just By Taking Keto Pills
