Weight loss is a challenging process, especially when diet and exercise alone don’t produce the desired results. Sometimes, medical intervention, such as weight loss pills prescribed by doctors, can help. These pills work in different ways: some suppress appetite, others boost metabolism, and a few block the body from absorbing fats. It’s essential to know which ones are safe, effective, and approved by health professionals.
In this article, we’ll explore the 11 best weight loss pills that doctors commonly recommend. We’ll break down what they do, how they work, and who they’re best suited for.
1. Phentermine
Phentermine is one of the most commonly prescribed weight loss medications. It’s an appetite suppressant, meaning it helps people eat less by making them feel full faster. Doctors typically prescribe it for short-term use, usually up to 12 weeks, as it can lead to weight loss when combined with a healthy diet and exercise.
Phentermine works by stimulating the release of chemicals in the brain that reduce hunger. It’s often used for people who are obese and have not been able to lose weight through lifestyle changes alone. However, it’s not suitable for people with certain heart conditions, high blood pressure, or hyperthyroidism.
2. Orlistat (Xenical or Alli)
Orlistat is a fat-blocking medication that prevents the body from absorbing about 25% of the fat you eat. It works by inhibiting the enzyme that breaks down fat in the gut, which means some of the fat passes through your system undigested. This can help reduce overall calorie intake and lead to weight loss.
Orlistat is available over-the-counter as Alli or in prescription form as Xenical. While it’s effective, it can cause digestive side effects like gas, oily stools, and diarrhea if you eat a high-fat meal. Doctors recommend it for people who are significantly overweight or obese and are committed to following a low-fat diet.
3. Lorcaserin (Belviq)
Lorcaserin was designed to help people lose weight by affecting the brain’s serotonin receptors, which control appetite and feelings of fullness. It makes you feel satisfied with smaller amounts of food, leading to reduced calorie intake.
This drug is generally well-tolerated and has fewer side effects than other weight loss pills. However, it was removed from the market in some countries due to concerns about potential cancer risks. It’s important to consult a doctor about the availability and risks associated with Lorcaserin.
4. Liraglutide (Saxenda)
Liraglutide is an injectable medication originally used to treat type 2 diabetes under the brand name Victoza. However, it’s also approved for weight loss in people who are overweight or obese under the name Saxenda. Liraglutide works by slowing down the emptying of the stomach, helping you feel full for longer and reducing your overall food intake.
This medication is usually prescribed for people with a body mass index (BMI) of 30 or higher, or 27 if they have weight-related conditions like diabetes or high blood pressure. It can be very effective when combined with lifestyle changes, but it must be injected daily and may cause nausea.
5. Phentermine-Topiramate (Qsymia)
Qsymia is a combination of two medications: phentermine, an appetite suppressant, and topiramate, a drug used to treat seizures and migraines. Together, they work to reduce hunger and make you feel full. Qsymia is prescribed for people with a BMI of 30 or higher, or 27 if they have conditions like diabetes or high blood pressure.
This drug is known for its effectiveness, with some people losing up to 10% of their body weight in a year. However, it may cause side effects like dry mouth, dizziness, and constipation. It’s also not safe for pregnant women.
6. Bupropion-Naltrexone (Contrave)
Contrave is another combination drug, consisting of bupropion (used to treat depression and help people quit smoking) and naltrexone (used to treat alcohol and opioid dependence). Together, these drugs target areas of the brain that control appetite and cravings.
Contrave can be effective for people who struggle with emotional eating, as it helps reduce food cravings and the desire to overeat. However, it may cause side effects like nausea, headache, and constipation. It’s not recommended for people with seizure disorders or uncontrolled high blood pressure.
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7. Semaglutide (Wegovy)
Semaglutide, marketed as Wegovy for weight loss, is another injectable medication that mimics a hormone called GLP-1, which helps regulate appetite and food intake. It works by slowing digestion and making you feel full after eating smaller amounts of food.
Semaglutide has been shown to help people lose significant weight, especially when combined with diet and exercise. Like Liraglutide, it’s typically prescribed for people with a high BMI and weight-related conditions. The most common side effects are nausea and diarrhea.
8. Plenity
Plenity is a relatively new, FDA-approved weight loss treatment. It’s a capsule made from naturally occurring cellulose, a fiber that absorbs water. When taken with water before meals, Plenity expands in the stomach, creating a feeling of fullness, which helps reduce food intake.
Plenity is not a drug but a medical device, making it different from other weight loss pills. It’s suitable for people with a BMI of 25 to 40 and can be used alongside diet and exercise. It has few side effects, with the most common being mild gastrointestinal discomfort.
9. Benzphetamine (Didrex)
Benzphetamine is another appetite suppressant that doctors prescribe for short-term weight loss. It’s similar to phentermine but is less potent. It works by stimulating the central nervous system, which helps reduce hunger and increase energy expenditure.
Doctors typically prescribe benzphetamine for people who need to jumpstart their weight loss journey but aren’t recommended to use it long-term. It can cause side effects like increased heart rate, dizziness, and insomnia, so it’s not suitable for everyone.
10. Diethylpropion (Tenuate)
Diethylpropion is another stimulant that works as an appetite suppressant. It’s usually prescribed for short-term use to help people reduce their calorie intake and lose weight. Diethylpropion helps suppress the urge to eat by affecting certain chemicals in the brain that regulate hunger.
This medication is usually well-tolerated, but it may cause side effects like dizziness, dry mouth, or insomnia. It’s typically used in conjunction with a reduced-calorie diet and exercise.
11. Setmelanotide (Imcivree)
Setmelanotide is a newer medication specifically designed for people with rare genetic conditions that cause obesity, such as POMC, PCSK1, or LEPR deficiency. It works by activating the melanocortin 4 receptor, which regulates hunger and energy expenditure.
Setmelanotide is an option for a very small group of people, but it can be life-changing for those with these genetic conditions. Common side effects include darkening of the skin and nausea.
Conclusion
Weight loss pills can be a useful tool for people struggling with obesity or weight-related conditions, but they are not a quick fix. The best weight loss pills are those prescribed by a doctor who can tailor them to your individual needs, medical history, and lifestyle. Remember, weight loss pills are most effective when combined with healthy eating habits and regular exercise.
Always talk to your doctor before starting any weight loss medication, as some pills come with side effects and are not suitable for everyone. By working with your healthcare provider, you can find a weight loss solution that works for you while staying safe and healthy.
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