In recent years, some new weight loss drugs have been developed one after another, some of which have been widely used in clinical practice.
Fenfluramine
For the current foreign introduced more, widely used weight loss drugs. Domestic production is now available. The role is to suppress appetite, reduce fat absorption, synthesis and accumulation, and promote fat decomposition. It is especially suitable for obese people with high blood pressure, coronary heart disease and diabetes. Adverse reactions were dry mouth, nausea, constipation or diarrhea. These reactions gradually diminished or disappeared with continuous administration. Another drowsiness, dizziness, headache, weakness, frequent urination and reactive depression. In severe cases, the symptoms disappeared after the drug was discontinued. Glaucoma, mentally ill patients disabled. After taking this drug for a long time, it should not be stopped suddenly, and the dose should be gradually reduced.
Amphetamine
Also known as diethylpropiophenone, diethylpropiophenone, etc., it is now produced in China. This drug acts on the hypothalamus and has a certain inhibitory effect on appetite. After 3-4 weeks of application, the body weight begins to decrease, and the effect is real. It can be combined with diet therapy to treat simple obesity or obesity with mild cardiovascular disease. Pregnant women and patients with epilepsy and hyperthyroidism are contraindicated or used with caution. Sudden withdrawal from prolonged use can cause fatigue and depression. Other adverse reactions include dry mouth, constipation, dizziness, drowsiness, occasional sweating, palpitations, excitement, insomnia, abdominal discomfort, nausea, and diarrhea.
Mazindole
Also known as Chlorbenzindole. It is a new type of appetite suppressant, commonly used in European and American countries. Its mechanism of action is similar to that of fenfluramine, and it has the pharmacological effect of directly reducing the body’s energy storage. Mainly used to treat obesity. Simple obesity and secondary obesity can be used with diet therapy. Secondary obesity should be treated first with the primary disease. Those who have no obvious short-term effect can be treated continuously for a long time. Mozindole can cause dry mouth, constipation, weakness, and some symptoms such as insomnia, chills, palpitations, headache, and nausea when used for a long time.
o-Chlorphentermine
Approved for use in the United States by the U.S. Food and Drug Administration, this product is a new long-acting appetite suppressant. Mainly acts on the hypothalamus satiety center to eliminate hunger and suppress appetite. It can reduce body weight satisfactorily, especially for exogenous obesity. The side effects are mild, mainly including excitement, increased blood pressure, insomnia, dry mouth, palpitations, and tachycardia. Hypertension and other cardiovascular system diseases, arrhythmias should be used with caution, and patients with hyperthyroidism and glaucoma should not be used.
Amirez
It is an effective appetite suppressant. The mechanism of action is similar to that of o-chlorphentermine, and the intensity of action is the same as that of amphirapone, which can significantly reduce the weight of obese patients. Appetite suppressing effect for up to 10-12 hours. Long-term use rarely develops tolerance. Common adverse reactions include nausea, vomiting, headache, dry mouth, insomnia, and slowed pulmonary circulation.
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