Approved by the State Food and Drug Administration, the National Center for Adverse Drug Reaction Monitoring issued the sixth phase of the “Notice of Adverse Drug Reaction Information”, reminding the public to use the weight loss drug fenfluramine hydrochloride, Chinese patent medicines containing aristolochic acid, and Imidazole anthelmintics such as levamisole.
Fenfluramine hydrochloride is a sympathomimetic amine derivative, an amphetamine appetite suppressant, used for obesity treatment. In view of the fact that fenfluramine hydrochloride can cause serious adverse reactions in the cardiovascular system, the National Center for Adverse Drug Reaction Monitoring recommends that patients must use such drugs under the guidance of physicians, and strictly control the indications and contraindications; patients with glaucoma and fenfluramine Or other sympathomimetic amine allergies are contraindicated; patients using monoamine oxidase inhibitors should avoid use within 14 days; patients with hypertension, cardiovascular disease, and depression should be used with caution, and should be monitored if used.
In recent years, domestic and foreign studies have confirmed that aristolochic acid has nephrotoxicity, and there are reports that aristolochic acid is carcinogenic. At present, aristolochic acid has been detected in the medicinal materials Guanmutong, Aristolochia, Qingmuxiang, Xungufeng, Guangfangji, and cinnabar lotus. Sexual issues have been cancelled by the State Food and Drug Administration for medicinal use. The National Center for Adverse Drug Reaction Monitoring recommends that patients must take Chinese herbal medicines or proprietary Chinese medicines containing aristolochic acid under the guidance of physicians, strictly control the dose and course of treatment, and pay attention to renal tubular and glomerular function monitoring during treatment.
Three imidazole anthelmintics such as levamisole, mebendazole and albendazole are broad-spectrum anthelmintics, which are clinically used for the anthelmintic treatment of roundworms, hookworms, cysticercosis, etc. Among them, levamisole is also used as an immunomodulatory agent . In view of the relationship between the three imidazoles and encephalitis syndrome, the National Center for Adverse Drug Reaction Monitoring recommends that patients use them under the guidance of doctors, and strictly grasp the indications and contraindications; doctors should ask patients about allergy history and family allergy history when prescribing; Those with a history of allergy to imidazole anthelmintics or a family history of allergy are contraindicated, and those with a history of allergy to other drugs should be used with caution. Relevant experts pointed out that drugs are like a double-edged sword. While they have therapeutic effects, there are bound to be adverse reactions. Therefore, a drug that has been notified of adverse reactions does not indicate that it is a substandard drug, nor should it be compared with “poison”, “fake drug”, “inferior drug” and “unusable”.
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