Metformin, a long-established medication used primarily for managing type 2 diabetes, has recently garnered attention for its potential role in weight loss. However, while some telehealth platforms are prescribing it for slimming down, experts caution that it’s no miracle drug for shedding pounds like Ozempic or Wegovy.
A Look at Metformin’s Origins and Function
Metformin, first derived from the French lilac plant and used as early as the 1700s, was originally thought to treat diabetes, which at the time was referred to as “sweet urine disease.” A more modern version was introduced in Europe in the 1950s and remains one of the most widely prescribed treatments for type 2 diabetes today. The drug works primarily by improving the body’s sensitivity to insulin and reducing the liver’s glucose production—two critical mechanisms in managing diabetes. These effects not only help to slow the progression of the disease but may also prevent it in those at risk.
Approved by the FDA for type 2 diabetes treatment in 1994, metformin has been used for a range of conditions, including polycystic ovary syndrome (PCOS) and gestational diabetes. In addition, studies suggest that it could offer protective benefits against heart disease, cancer, stroke, and even dementia, positioning it as a potential “wonder drug” in certain medical circles.
Metformin and Weight Loss: Modest Effects
While not initially prescribed for weight loss, metformin is sometimes associated with modest weight reduction. However, experts emphasize that it is far from a primary tool for slimming down. According to Dr. Arti Thangudu, an endocrinologist, research typically shows weight loss of only 2% to 3% of body weight among those using the drug. A recent study suggested that metformin might mimic the appetite-regulating effects of vigorous exercise, but its overall impact remains limited.
“Most of the data we see finds metformin to be fairly weight-neutral,” Thangudu explains. Unlike FDA-approved medications like Wegovy, which are specifically designed for weight loss, metformin doesn’t have the clinical backing to be considered a weight loss solution. It’s also not without side effects, including gastrointestinal issues like nausea and diarrhea, which can be managed by adjusting the dosage or taking an extended-release version.
Why Some Telehealth Services Are Prescribing Metformin for Weight Loss
Despite its limited effects on weight loss, some telehealth providers, such as Hims & Hers, have included metformin in weight loss medication kits. These kits also contain other drugs that might suppress appetite or help with cravings. While metformin may cause slight weight loss for some individuals, Dr. Scott Kahan, director of the National Center for Weight and Wellness, warns that relying on such a drug to achieve significant weight loss may set unrealistic expectations.
“Metformin may have a modest impact, but it’s not typically used for weight loss due to the lack of strong evidence,” Kahan says. Hims & Hers markets the drug as part of its “Medication Kit 1,” which also includes medications for addiction, appetite suppression, and vitamin B12. While none of these drugs are contraindicated when used together, experts caution that the combination may not provide lasting or significant weight loss results.
The Cost Factor: Why Some Turn to Metformin for Weight Loss
One of the main attractions of metformin, particularly for those considering weight loss options, is its cost-effectiveness. While weight loss medications like Ozempic can cost nearly $1,000 per month without insurance, metformin is significantly more affordable, with a month’s supply of the generic version costing between $10 and $30. This price difference makes it an attractive alternative, even if its effects on weight loss are minimal.
However, while some users have reported losing several pounds while on metformin, these results are generally modest and often combined with other lifestyle changes, such as exercise. Success stories on forums like Reddit show users losing weight after using the medication in conjunction with other drugs in the kit, but experts emphasize that these instances are outliers.
Is Metformin Right for You?
Before considering metformin for weight loss, experts agree that it’s crucial to consult with a healthcare provider to ensure it’s safe for you and that it aligns with your goals. While the drug may be appropriate for some individuals, especially those who do not have underlying health conditions such as kidney or liver disease, it is not a guaranteed solution for weight loss.
Dr. Kahan also suggests that patients should expect to see results within a reasonable timeframe. If, after several months, there is little to no weight loss, it may be time to explore alternative treatments.
In conclusion, while metformin is a low-cost and widely available option, its role in weight loss should not be overstated. It’s not a magic bullet, and for those with higher weight loss goals, FDA-approved treatments like Ozempic may be more effective.
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