Comedian Jim Gaffigan has become the latest celebrity to share his weight-loss journey, attributing his transformation to the popular medication Mounjaro. The 58-year-old comedian, best known for his self-deprecating humor, told People magazine that he lost 50 pounds using the prescription drug, which is primarily prescribed for Type 2 diabetes but also helps with weight loss.
“I feel good,” Gaffigan shared in the interview. “I’m just grateful because it’s such a better life.”
The comedian, who once weighed approximately 270 pounds, turned to Mounjaro, the brand name for tirzepatide, after years of struggling with his weight. Initially skeptical about its effectiveness, he recalled hearing from a friend that the medication only caused nausea. However, Gaffigan’s mindset changed once he began seeing results.
“I had very low expectations because I did know someone that had tried it and they were like, ‘Oh no, I was just nauseous for a week,’” Gaffigan explained. “And then I thought my true joy of eating would overpower anything.”
Throughout his adult life, Gaffigan has battled with his weight, often exercising intensely to stay thin enough to indulge in food. He described how his metabolism slowed down as he aged, making weight loss even more challenging. “Then my knees started giving out, and then fatigue set in,” he added.
In his latest stand-up special, The Skinny, which premieres on Hulu on November 22, Gaffigan opens up further about his weight-loss experience. “I don’t know if you know, I’m normally a fat guy. But since I’ve lost all this weight, I’m just arrogant,” he jokes. “People — they won’t even say anything to me — they’ll just go up to my wife and ask, ‘Is Jim OK?’ Because to them, it’s more likely that I’m sick than I would ever have any self-discipline.”
Gaffigan joins a growing list of celebrities, including Amy Schumer, Whoopi Goldberg, and Oprah Winfrey, who have publicly discussed their use of weight-loss medications such as Ozempic, Wegovy, and Zepbound. As one of the few male stars to openly talk about his experience, Gaffigan hopes to challenge the stigma surrounding weight-loss drugs.
“… that’s some of why I wanted to talk about it, because I almost thought it was kind of odd that people were resistant to talking about it,” he said. “I don’t think there’s anything wrong with it. There’s people walking around that obviously do not have blonde hair — yet they do. I don’t think that’s weird, either. It’s just whatever gets you through.”
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